The Evidence: Research & Clinical Studies

Some of the many health-related research and clinical studies which have been done on Irvingia Gabonensis (African Mango).

Last updated: October 15, 2014

Studies on Irvingia and Weight Loss


The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon
Lipids in Health and Disease, May 25, 2005
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168905/

The first clinical trial examining the effect of Irvingia gabonensis on weight loss. Full text.

The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.
Lipids in Health and Disease, March, 2008
http://www.lipidworld.com/content/7/1/12

This study evaluated the effects of two formulations, Cissus quadrangularis-only and a Cissus quadrangularis/Irvingia gabonensis combination, on weight loss. Study involved 72 participants over a 10 week period. While both groups showed significant reductions compared to the placebo group, those taking the Irvingia combo had the best results.

Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene
Lipids in Health and Disease. November 13, 2008
http://www.lipidworld.com/content/7/1/44

In-vitro study of African Mango seed extract on the biology of fat cell priduction, through its effect on PPAR gamma, adiponectin, and leptin. The study concluded that the irvingia extract (IGOB131) might "have further implications in in-vivo anti obesity effects by targeting the PPAR gamma gene, a known contributory factor to obesity in humans"

IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.
Lipids in Health and Disease, March, 2009
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651880/

A follow-up to the March 2009 in-vitro research, this 10 week study was conducted upon 102 healthy, overweight and/or obese participants. The results indicated "significant improvements in body weight, body fat, and waist circumference as well as plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels" in the subjects taking IGOB131 (African mango seed extract) compared to the placebo group. The study concluded that "Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome."

An Evidence-Based Review of Fat Modifying Supplemental Weight Loss Products
Journal of Obesity, 2011
http://www.hindawi.com/journals/jobe/2011/297315/

A look at the evidence supporting several fat-modifying weight-loss supplements. The study concluded that African Mango has "shown some potential benefit for weight loss" however "more data is necessary to draw any definitive conclusions on the use of dietary supplements for weight loss" and "continued is needed."

Product Integrity:

Ultra high-performance liquid chromatography with high-resolution mass spectrometry analysis of African mango(Irvingia gabonensis) seeds, extract, and related dietary supplements.
Journal of Agricultural and Food Chemistry, August 23, 2012
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506011/

This study examined ways to detect the presence of African mango seed extract in a product, and concluded that several supplements on the market (manufactured offshore) contained NO detectable amount of African mango seed, despite their label claims to the contrary. The study authors call for the enforcement of the FDA's GMP (Good Manufacturing Practices) requirements for the dietary supplement industry.

 

Other Health Related Studies


Safety

Subchronic toxicity and mutagenicity/genotoxicity studies of Irvingia gabonensis extract (IGOB131).
Food and chemical toxicology, May, 2012
http://www.ncbi.nlm.nih.gov/pubmed/22386809

This toxicity study concluded that there was "no-observed-adverse-effect level (NOAEL) for I. gabonensis extract (IGOB131) as ≥ 2500 mg/kg of body weight per day -the highest dose tested.


Lipid Profiles and Cholesterol

(See also: Weight Loss studies)

Hypolipidemic and antioxidative effects of dika nut (Irvingia gabonensis) seeds and nkui (Trimphetta cordifolia) stem bark mucilages in triton WR-1339 induced hyperlipidemic rats
Food Science and Biotechnology, December 2012
http://link.springer.com/article/10.1007%2Fs10068-012-0228-5

Irvingia gabonensis fat: nutritional properties and effect of increasing amounts on the growth and lipid metabolism of young rats
Lipids in Health and Disease, March 4, 2011
http://www.lipidworld.com/content/10/1/43


Diabetes

Digestive and hepatic enzymes in streptozotocin-induced diabetic rats fed supplements of dikanut (Irvingia gabonensis) and cellulose
Annals of Nutrition & Metabolism, 1993
http://www.ncbi.nlm.nih.gov/pubmed/8385893

A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics
West African Journal of Medicine, June, 1990
http://www.ncbi.nlm.nih.gov/pubmed/2148494

Small study, human participants.

More data on the effect of I. gabonensis on glucose levels can be found on several of the weight loss studies.


Gastrointestinal

Effect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodents
Indian Journal of Experimental Biology, August, 2004
http://www.ncbi.nlm.nih.gov/pubmed/15573528

Demonstrated the ability of African mango leaf extract to control diarrhea in rodents.


Antibiotic / Antifungal Properties

Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis
Journal of Ethnopharmacology, October, 2007
http://www.ncbi.nlm.nih.gov/pubmed/17766070

"The obtained results confirmed the use of Irvingia gabonensis in the treatment of bacterial and fungal infections."


Analgesic Properties

Analgesic effect of Irvingia gabonensis stem bark extract
Journal of Ethnopharmacology, February, 1995
http://www.ncbi.nlm.nih.gov/pubmed/7776661?report=abstract

In-vivo study, conducted on mice.

 

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